抗體藥物課件

1、抗體藥物的研究與應(yīng)用The Research and Application of Antibody Drug蔣瑜2015-8-1全球抗體藥物研發(fā)品種年度概覽圖GAO Yun-hua et al. Chinese Journal of New Drugs 2014抗體藥物研發(fā)各階段分布圖GAO Yun-hua et al. Chinese Journal of New Drugs 2014抗體藥物主要作用靶點(diǎn)藥物分布圖GAO Yun-hua et al. Chinese Journal of New Drugs 2014上市抗體藥物主要適應(yīng)癥分布圖GAO Yun-hua et al. Chin

2、ese Journal of New Drugs 2014各大公司失效專利數(shù)量分布圖GAO Yun-hua et al. Chinese Journal of New Drugs 2014抗體藥物研究文獻(xiàn)地區(qū)分布情況 國家 占比/% 文獻(xiàn)量/篇 USA 154 621 36 30 JAPAN 50 080 11 76GERMANY 38 360 9 00ENGLAND 31 014 7 28 FRANCE 26 106 6 13 ITALY 20 935 4 91 CHINA 20 754 4 87 CANADA 17 607 4 13 NETHERLANDS 14 321 3 36 SPAI

3、N 12 873 3 02GAO Yun-hua et al. Chinese Journal of New Drugs 2014CFDA已批準(zhǔn)上市的抗體藥物截至2013年9月 魏梁,趙志剛; 藥品評(píng)價(jià) 2014PET Imaging of a 76Br-Labeled Monoclonal Anti-CEA Antibody Lovqvist et al. THE JOURNAL OF NUCLEAR MEDICINE 1997 In vivo evaluation with High 124I-labeled minibody variants Eric J. Lepin et al. E

4、ur J Nucl Med Mol Imaging 2010 Immuno-PET 68 Ga-IMP-288 in a patient with metastatic breast carcinomaKraeber-Bodr F et al. Frontiers in Pharmacology 2015 PET/CT imaging and biodistribution of 64Cu-NOTA-AC133 mAb Gaedicke et al. PNAS 2014Factors to consider when designing an immunoPET tracerAnna M. Wu e