7-Chloro-4-hydroxyquinoline-2-carboxylic-acid-7-Chlorokynurenic-acid-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE7-Chloro-4-hydroxyquinoline-2-carboxylic acidCat. No.: HY-100811CAS No.: 18000-24-3Synonyms: 7-Chlorokynurenic acid分式: CHClNO分量: 223.61作靶點(diǎn): iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C

2、 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 30 mg/mL (134.16 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.4721 mL 22.3604 mL 44.7207 mL5 mM 0.8944 mL 4.4721 mL 8.9441 mL10 mM 0.4472 mL 2.2360 mL 4.4721 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存

3、式和期限。BIOLOGICAL ACTIVITY物活性 7-Chloro-4-hydroxyquinoline-2-carboxylic acid (7-Chlorokynurenic acid)是N-甲基-D-天冬氨酸受體復(fù)合物氨酸調(diào)節(jié)位點(diǎn)上的選擇性拮抗劑，并且能有效抑制氨酸被重 吸收到突觸泡中, 其 Ki 值 0.59 M。IC50 & Target N-methyl-D-aspartate receptor 1Ki: 0.59 M (reuptake of glutamate) 11/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEREFER

4、ENCES1. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptorcomplex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.2. Bartlett RD, et al. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology. 1998Jul;37(7):839-46.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa