Avosentan-Ro-67-0565-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAvosentanCat. No.: HY-15195CAS No.: 290815-26-8Synonyms: Ro 67-0565; SPP-301分式: CHNOS分量: 479.51作靶點(diǎn): Endothelin Receptor作通路: GPCR/G Protein儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 6.6

2、7 mg/mL (13.91 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 0.67 mg/mL (1.40 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 0.67 mg/mL (1.40 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Avosentan(Ro 67-0565; S

3、PP-301)內(nèi)素（ETA）受體拮抗劑。REFERENCES1. Baltatu OC, Iliescu R, Zaugg CE, Reckelhoff JF, Louie P, Schumacher C, Campos LA. Antidiuretic effects of the endothelin receptorantagonist avosentan. Front Physiol. 2012;3:103.2. Konieczka K, Meyer P, Schoetzau A, Neutzner A, Mozaffarieh M, Flammer J. Effect of avos

4、entan (SPP-301) in porcine ciliary arteries.Curr Eye Res. 2011 Feb;36(2):118-24.3. Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G; ASCEND Study Group. J Am Soc Nephrol. 2010Mar;21(3):527-35.4. Dieterle W, Hengelage T. Absolute bioavailability and pharmacokinetics of avose

5、ntan in man. Int J Clin Pharmacol Ther. 2009Sep;47(9):587-94.5. Effect of SPP 301, an Endothelin Antagonist, on Intraocular Pressure in Glaucomatous Monkey Eyes By Wang, Rong-Fang; Podos,Steven M.; Serle, Janet B.; Baltatu, Ovidiu C. From Current Eye Research (2011), 36(1), 41-46.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-