SB297006 _CCR Antagonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESB297006Cat. No.: HY-103361CAS No.: 58816-69-6分式: CHNO分量: 342.35作靶點(diǎn): CCR作通路: GPCR/G Protein; Immunology/Inflammation儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗 DMSO : 150 mg/mL (438.15 mM; Nee

2、d ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.30 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.30 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 SB297006種 CCR3 拮抗劑，能夠顯著抑制 CCL11 處理的神經(jīng)祖細(xì)胞的增殖和神經(jīng)球

3、形成。IC50 & Target CCR3 1體外研究 SB297006 is a CCR3 antagonist, significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells (NPCs) at 100 M 1.PROTOCOLCell Assay 1 To evaluate CCR3 blocking, neural progenitor cells (NPCs) are incubated with the CCR3 antagonistSB

4、297006 (100 M) for 30 minutes and then stimulated with CCL11 (2 g/mL). After 3 days of culture, NPCsare subjected to CCK-8 assays 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Wang F, et al. CCL11 promotes migration and proliferation of mouse neural progenitor cells. Stem Cell Res Ther. 2017 Feb 7;8(1):26.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F