Mycophenolic-acid-Mycophenolate-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMycophenolic acidCat. No.: HY-B0421CAS No.: 24280-93-1Synonyms: Mycophenolate分式: CHO分量: 320.34作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (312.17 mM)H2O

2、: 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.80 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.80 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.80 mM); Clear

3、 solutionBIOLOGICAL ACTIVITY物活性 Mycophenolic acid (Mycophenolate)是免疫抑制劑，有抗增殖活性。IC50 & Target Mycophenolic acid (MPA) is an immunosuppressant drug used to prevent rejection in organ transplantation.It inhibits an enzyme needed for the growth of T cells and B cells. Mycophenolic acid (MPA) did not blo

4、ck theinitial phase of viral translation but did interfere with viral protein synthesis in the amplification phase.Quantitative RT-PCR demonstrated that MPA prevented the accumulation of viral positive- and negative-strand RNA as the infection proceeded. Mycophenolic acid (MPA) inhibits flavivirus i

5、nfection by preventingsynthesis and accumulation of viral RNA 1. The effects of Mycophenolic acid (MPA) on DEN replication inmonkey kidney (LLC-MK2) cells were examined. MPA (IC50=0.4+/-0.3 microM) inhibited DEN2 replication.Quantitative real-time RT-PCR of viral RNA and plaque assays of virions fro

6、m DEN2-infected andMycophenolic acid (MPA) (10 microM) -treated cells showed a fivefold increase in defective viral RNAproduction by cells treated with each drug. suggesting that one mode of antiviral action of MPA is byinhibition of inosine monophosphate dehydrogenase and thereby depletion of the i

7、ntracellular GTP pool 2.REFERENCES1. Diamond, M.S., M. Zachariah, and E. Harris, Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA.Virology, 2002. 304(2): p. 211-21.2. Takhampunya, R., et al., Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol, 2006. 87(Pt 7): p. 1947-52.McePdfHeightCaution: Product has not been fully validated for medical applications.For research