病毒暨細胞生物研究室

1、病毒暨細胞生物研究室壹、個人基本資料姓 名：施玟玲電 話：08-7703202-5192電子郵件：.tw學 歷：臺灣大學微生物學研究所博士專 長：1. 微生物學 2.分子病毒學 3. 分子及細胞生物學 4.細胞凋亡 5. 訊息傳遞 貳、近五年研究方向【一】自體能動分泌因子/磷酸葡萄糖異構(gòu)酵素（autocrine motility factor/phosphoglucose isomerase；AMF/PGI）誘發(fā)腫瘤細胞轉(zhuǎn)移與抗細胞凋亡及對細胞週期影響的分子研究?！径吭隗w外及活體內(nèi)探討動物病毒引發(fā)細胞凋亡，抗細胞凋亡，細胞自噬與發(fā)炎反應(yīng)之分子機制，主要

2、研究對象為家禽里奧病毒（avian reovirus；ARV）及其S1基因產(chǎn)物與豬假性狂犬病病毒（pseudorabies virus；PRV）?！救坑苫ㄉ忁r(nóng)改場培育的花蓮一號苦瓜種子中選殖、表現(xiàn)及純化苦瓜核糖體失活蛋白MAP30，檢測其是否具抑制人類B型肝炎病毒複製及豬隻重要傳染性細菌及病毒的研究，期望未來可能進一步開發(fā)成臨床使用的生物製劑。參、發(fā)表著作A. 期刊論文 (根據(jù)Journal Citation Report (JCR) 2006年) * corresponding author 1 first author(According to the Journal Citation

3、Report 2007)1. 1Wen-Ling Shih, Ming-Liang Kuo, Shuang-En Chuang, Ann-Lii Cheng, Shin-Lian Doong. Hepatitis B Virus X Protein Inhibits Transforming Growth Factor-b-induced Apoptosis through the Activation of Phosphatidylinositol 3-Kinase Pathway. The Journal of Biological Chemistry 275(33): 25858-258

4、64, 2000 (SCI, IF:, ranking: /, %, ) (獲八十九學年度臺大醫(yī)學院論文競賽傑出著作獎)2. Hung J. Liu, Long H. Lee, Wen L. Shih, Maw Y. Lin, Ming H. Liao. Detection of infectious bronchitis virus by multiplex polymerase chain reaction and sequence analysis. Journal of Virological Methods 109(1): 31-37, 2003 (SCI, IF: 1.933, r

5、anking: 71/138, 51.4%, Biotechnology and Applied Microbiology)3. 1Wen-Ling Shih, Shuang-En Chuang, Ann-Lii Cheng, Shin-Lian Doong. Hepatitis B virus X protein activates a survival signaling by linking Src to Phosphatidylinositol 3-kinase.The Journal of Biological Chemistry 278(34): 31807-31813, 2003

6、 (SCI, IF: , ranking:/ , %,) (獲九十三年肝病防治學術(shù)基金會優(yōu)秀論文獎)4. 1Wen- Ling Shih, Hsiao-Wei Hus, Ming-Huei Liao, Long-Huw, Lee, Hung-Jen Liu. Avian reovirus sC protein induces apoptosis in cultured cells. Virology, 321(1): 65-74, 2004 (SCI, IF: 3.765, ranking: 6/25, 24.0%, Virology) 5. Hung J. Liu, Long H. Lee,

7、 Wen L. Shih, Ying J. Li, Hung Y. Su. Rapid characterization of avian reoviruses using phylogenetic analysis, reverse transcription-polymerase chain reaction and restriction enzyme fragment length polymorphism.Avian Pathology, 33(2):171-180, 2004 (SCI, IF: 1.257, ranking: 32/133, 24.1%, Veterinary S

8、cience) 6. Feng-Ling Yu, Ming-Huei Liao, Jeng-Woei Lee, Wen-Ling Shih*. Induction of hepatoma cells migration by phosphoglucose isomerase / autocrine motility factor through the upregulation of matrix metalloproteinase-3. Biochemical and Biophysical Research Communications, 314(1): 76-82, 2004(SCI,

9、IF: 2.749, ranking: 27/69, 39.1%, Biophysics)7. Chia-Jung Chang, Wen-Ling Shih, Feng-Ling Yu, Ming-Huei Liao, Hung-Jen Liu. Apoptosis induced by bovine ephemeral fever virus. Journal of Virological Methods, 122(2):165-170, 2004(SCI, IF: 1.933, ranking: 71/138, 51.4%, Biotechnology and Applied Microb

10、iology)8. Feng-Ling Yu, Hung-Jen Liu, Jeng-Woei Lee, Ming-Huei Liao, Wen-Ling Shih*. Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3.Journal of Hepatology, 42(2):520-527, 2005(SCI, IF: 6.642, ranking: 4/50, 8.0%, Gastroenterology and Hepatology) 9. Hung-Jen

11、 Liu, Ping-Yuan Lin, Jeng-Woei Lee, Hsue-Yin Hsu, Shih WL*. Retardation of cell growth by avian reovirus p17 through the activation of p53 pathway.Biochemical and Biophysical Research Communications, 336(2):709-715, 2005(SCI, IF: 2.749, ranking: 27/69, 39.1%, Biophysics)10. Chien J. Hsu, Chi Y. Wang

12、, Long H. Lee , Wen L. Shih, Chi I. Chang, Hsueh L. Cheng, Julius L. C. Chulu, Wen T. Ji , Hung J. Liu. Development and characterization of monoclonal antibodies against avian reovirus S1133 sC protein and their application in detection of ARV isolates.Avian Pathology, 35(4): 320-326, 2006(SCI, IF:

13、1.257, ranking: 32/133, 24.1%, Veterinary Science)11. Ping-Yuan Lin, Hung-Jen Liu, Meng-Jiun Lai, Feng-Ling Yu, Hsue-Yin Hsu, Jeng-Woei Lee, Wen-Ling Shih*. Avian Reovirus activates a novel proapoptotic signal by linking Src to p53.Apoptosis, 11:2179-2193, 2006 (SCI, IF: 3.043, ranking: 105/263, 39.

14、9%, Biochemistry and Molecular Biology)12. Hsin Y. Lin, Sue T. Chuang, Yu T. Chen, Wen L. Shih, Ching D. Chang, Hung J. Liu. ARV-induced apoptosis related to tissue injury. Avian Pathology, 36(2):155-159, 2007(SCI, IF: 1.257, ranking: 32/133, 24.1%, Veterinary Science)13. Julius L.C. Chulu, Long H.

15、Lee, Ya C. Lee, Shu H. Liao, Feng L. Lin, Wen L. Shih*, Hung J. Liu*. Apoptosis induction by avian reovirus through p53 and mitochondria-mediated pathway.Biochemical and Biophysical Research Communications, 356(3):529-535, 2007(SCI, IF: 2.749, ranking: 27/69, 39.1%, Biophysics)14. Jeng-Woei Lee, Kue

16、i-Fang Lee, Hsue-Yin Hsu, Lee-Ping Hsu, Wen-Ling Shih, Yi-Chih Chu, Wei-Ting Hsiao, Po-Fan Liu. Protein expression and intracellular localization of prostate apoptosis response-4 (Par-4) are associated with apoptosis induction in nasopharyngeal carcinoma cell lines.Cancer Letters, 257(2):252-262, 20

17、07(SCI, IF: 3.398, ranking: 49/132, 37.1%, Oncology)15. 1 Wen-Ling Shih *, Ming-Huei Liao, Feng-Ling Yu, Ping-Yuan Lin, Hsue-Yin Hsu, Shu-Jun Chiu. AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-phosphatidylinositol 3-kinase signaling to induce hepatoma cell migration.Cance

18、r Letters, 270(2):202-217, 2008(SCI, IF: 3.398, ranking: 49/132, 37.1%, Oncology)16. Hung-Jen Liu, Ping-Yuan Lin, Ling-Rung Wang, Hsue-Yin Hsu, Ming-Huei Liao, Wen-Ling Shih*. Activation of Small GTPases RhoA and Rac1 is required for Avian Reovirus p10-induced syncytium formation.Molecules and Cells

19、, 26(4):396-403, 2008 (SCI, IF: 1.916, ranking: 177/263, 67.3%, Biochemistry and Molecular Biology)17. Ching-Ju Yeh, Ping-Yuan Lin, Ming-Huei Liao, Hung-Jen Liu, Jeng-Woei Lee, Shu-Jun Chiu, Hsue-Yin Hsu, Wen-Ling Shih*. TNF- mediates Pseudorabies Virus-induced Apoptosis via the Activation of p38 MA

20、PK and JNK/SAPK Signaling.Virology, 381(1):55-66, 2008 (SCI, IF: 3.765, ranking: 6/25, 24.0%, Virology)18. Yueh H. Lin, Long H. Lee, Wen L. Shih, Yu C. Hu, Hung J. Liu. Baculovirus surface display of sigmaC and sigmaB proteins of avian reovirus and immunogenicity of the displayed proteins in a mouse

21、 model. Vaccine, 26(50):6361-6367, 2008 (SCI, IF: 3.377, ranking: 2/133, 1.5%, Veterinary Science)19. Ping-Yuan Lin, Jeng-Woei Lee, Ming-Huei Liao, Hsue-Yin Hsu, Shu-Jun Chiu, Hung-Jen Liu*, Wen-Ling Shih*. Modulation of p53 by Mitogen-activated Protein Kinase Pathways and Protein Kinase C d during

22、Avian Reovirus S1133-induced ApoptosisVirology, 385:323-334, 2009(SCI, IF: 3.765, ranking: 6/25, 24.0%, Virology)20. Jeng-Woei Lee, Po-Fan Liu, Lee-Ping Hsu, Peir-Rong Chen, Chung-Hsing Chang, Wen-Ling Shih. EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyng

23、eal carcinoma cells.Cancer Letters, 279(2):193-201, 2009(SCI, IF: 3.398, ranking: 49/132, 37.1%, Oncology)21. Xin-Gang Xu, De-Wen Tong, Ming-Tang Chiou, Yao-Ching Hsieh, Wen-Ling Shih, Ching-Dong Chang, Ming-Huei Liao, Yan-Ming Zhang, Hung-Jen Liu.Journal of Virological Methods, 159(2):259-264, 2009

24、(SCI, IF: 1.933, ranking: 71/138, 51.4%, Biotechnology and Applied Microbiology)22. Chi-Hung Lin, Wen-Ling Shih, Feng-Lang Lin, Yao-Ching Hsieh, Yur-Ren Kuo, Ming-Huei Liao, Hung-Jeng Liu. Bovine ephemeral fever virus-induced apoptosis requires virus gene expression and activation of Fas and mitocho

25、ndrial signaling pathway.Apoptosis, 14:864-877, 2009 (SCI, IF: 3.043, ranking: 105/263, 39.9%, Biochemistry and Molecular Biology)23. Jeng-Woei Lee, Wei-Ting Hsiao, Hsia-Yun Chen, Lee-Ping Hsu, Peir-Rong Chen, Ming-Der Lin, Shu-Jun Chiu, Wen-Ling Shih, Yih-Chih Hsu. Up-regulated claudin-1 expression

26、 confers resistance to cell death of nasopharyngeal carcinoma cells.International Journal of Cancer, (accepted), 2009(SCI, IF: 4.734, ranking: 30/143, 21.0%, Oncology)24. Wen-Ling Shih*, Ming-Huei Liao, Ping-Yuan Lin, Chi-I Chang, Hsueh-Ling Cheng, Feng-Ling Yu and Jeng-Woei Lee. PI 3-kinase/Akt and

27、 STAT3 are required for the prevention of TGF-induced Hep3B cell apoptosis by autocrine motility factor/phosphoglucose isomerase Cancer Letters, (accepted), 2009(SCI, IF: 3.398, ranking: 49/132, 37.1%, Oncology)25. Chun-Yen Chen, Chin-Yang Chang, Hung-Jen Liu, Ming-Huei Liao, Chi-I Chang, Jue-Liang

28、Hsu, Wen-Ling Shih*. Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathwaysVeterinary Research, (accepted), 2009(SCI, IF:3.060 , ranking: 3/135, 2.2%, Veterinary Science) B. 研討會論文* corresponding author 1 first

29、author1. 1999/4 第四屆臺灣癌癥聯(lián)合學術(shù)年會，臺北榮民總醫(yī)院。1Wen-Ling Shih, Shuang-En Chuang, Ann-Lii Cheng, Shin-Lian Doong. Inhibition of TGF-b-induced Apoptosis by Hepatitis B Virus X Protein (獲優(yōu)秀壁報論文獎)2. 1999/8 8th International Symposium of Society of Chinese Bioscientists in America, Hong Kong Convention and Exhibi

30、tion Center, Hong Kong, China. 1Wen-Ling Shih, Shuang-En Chuang, Ann-Lii Cheng, Shin-Lian Doong. Inhibition of TGF-b-induced Apoptosis by Hepatitis B Virus X Protein3. 2000/12 Hepatitis and Hepatocellular carcinoma: Novel Approaches Joint conference of the National Health Research Institute and Amer

31、ican Association for Cancer Research , 宏碁渴望中心。1Wen-Ling Shih, Shin-Lian Doong. Association of Hepatitis B Virus X Protein with the Periplasm Cellular Membrane4. 2001/2 3rd NHRI Conference on Viral Hepatitis and Hepatocellular Carcinoma, 中央研究院。 1Wen-Ling Shih, Shuang-En Chuang, Ann-Lii Cheng, Shin-Li

32、an Doong. Hepatitis B Virus X Protein Inhibits Transfroming Growth Factor-b -induced Apoptosis through the Activation of Phosphatidylinositol 3-Kinase Pathway5. 2001/7 The 8th East Asian Joint Symposium on Biomedical Research. Japan (oral presentation).1Wen-Ling Shih, Shuang-En Chuang, Ann-Lii Cheng

33、, Shin-Lian Doong. Hepatitis B Virus X Protein Activates a Survival Signaling by Linking Src to Phosphatidylinositol 3-Kinase6. 2002/12 教育部產(chǎn)學合作成果發(fā)表，屏東科技大學。張家榮，施玟玲，尤封陵，廖明輝。牛流行熱基因工程疫苗之研製。7. 2003/5 畜牧獸醫(yī)春季研討會，中興大學。劉宏仁、李英瑞、張清俊、施玟玲、李龍湖、廖明輝、張清棟。應(yīng)用RT-PCR及RFLP技術(shù)快速鑑定家禽里奧病毒。8. 2003/5 畜牧獸醫(yī)春季研討會，中興大學。劉旭展、尤封陵、施玟玲

34、、劉宏仁、廖明輝。豬環(huán)狀病毒之分子診斷與基因分析。9. 2003/5 畜牧獸醫(yī)春季研討會，中興大學。呂美齡、施玟玲、劉宏仁、張清棟、廖明輝。應(yīng)用RT-PCR檢測犬瘟熱病毒基因及其親源關(guān)係分析。10. 2003/5 畜牧獸醫(yī)春季研討會，中興大學。徐曉微、李龍湖、施玟玲、廖明輝、劉宏仁。家禽里奧病毒C蛋白是凋亡素(apoptin)。11. 2003/5 畜牧獸醫(yī)春季研討會，中興大學。張家榮，施玟玲，尤封陵，劉宏仁，劉世賢，廖明輝。牛流行熱病毒誘發(fā)細胞凋亡之研究。12. 2005/5 畜牧獸醫(yī)春季研討會，屏東科技大學。李雅純，施玟玲，劉宏仁。家禽里奧病毒誘發(fā)細胞凋亡機制之探討。13. 2005/5

35、畜牧獸醫(yī)春季研討會，屏東科技大學。林欣怡，施玟玲，張清棟，李龍湖，劉宏仁。家禽里奧病毒感染雞隻誘發(fā)組織凋亡之研究。14. 2006/3 第二十一屆生物醫(yī)學學術(shù)研討會，國防大學。(獲優(yōu)秀壁報論文獎)Ping-Yuan Lin, Hung-Jen Liu, Hsue-Yin Hsu and Wen-Ling Shih*. Avian reoviruses activate a proapoptotic signal by linking Src to p53.15. 2006/5 畜牧獸醫(yī)春季研討會，嘉義大學。林炳源，劉宏仁，徐雪瑩，李政偉，施玟玲*。 Avian reoviruses activ

36、ate a proapoptotic signal by linking Src to p53.16. 2006/5 畜牧獸醫(yī)春季研討會，嘉義大學。Julius L.C. Chulu，鄭雪玲，施玟玲，機文財，劉宏仁。Avian Reovirus-Induced p17 Dependent G2/M Phase Cell Cycle Arrest.17. 2006/6 慈濟大學九十四年度學術(shù)研討會。(獲優(yōu)秀壁報論文獎)Ping-Yuan Lin, Hung-Jen Liu, Hsue-Yin Hsu and Wen-Ling Shih*. Avian reoviruses activate a

37、proapoptotic signal by linking Src to p53. 18. 2006/6 慈濟大學九十五年度學術(shù)研討會。Ching-Ju Yeh, Ping-Yuan Lin, Feng-Ling Yu, Hsue-Yin Hsu, Wen-Ling Shih*.Activation of p38 Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase signal transduction pathways in Pseudorabies Virus-induced apoptosis.19. 2006/11

38、 IMB 20th Anniversary Symposium, Academia Sinica.Yung-Ping Li, Jong-Ho Chyuan ,Wen-Ling Shih and Ching-Ming Cheng. Characterization and application of functional genes of Momordica charantia.20. 2007/5 畜牧獸醫(yī)春季研討會，臺灣大學。Julius L. C. Chulu, Wen T. Ji, Wen L. Shih , Shieh L. Cheng , and Hung J. Liu. Avia

39、n Reovirus p17 Protein Causes G2/M Cell Cycle Arrest Through Phosphorylation of Cdc2.21. 2007/5 病毒研究新知研討會，慈濟大學。(獲優(yōu)秀壁報論文獎)Ching-Ju Yeh, Ping-Yuan Lin, Ming-Huei Liao, Wen-Ling Shih*. Tumor Necrosis Factor-a mediates Pseudorabies Virus-induced Apoptosis via the Activation of p38 Mitogen-activated Prot

40、ein Kinase and c-Jun N-terminal Kinase /Stress-activated Protein Kinase Signaling. 22. 2007/5 病毒研究新知研討會，慈濟大學。Tsung-Chi Huang, Ming-Huei Liao, Wen-Ling Shih*. Involvement of DNA-damage Pathway in Pseudorabies Virus-induced Apoptosis. 23. 2007/5 病毒研究新知研討會，慈濟大學。(獲優(yōu)秀壁報論文獎)Ping-Yuan Lin, Hung-Jen Liu, Mi

41、ng-Huei Liao, Wen-Ling Shih*. Modulation of p53 activity by Mitogen-activated Protein Kinase pathway and protein kinase C d signaling during Avian Reovirus induced apoptosis.24. 2007/6 慈濟大學九十六年度學術(shù)研討會。Ching-Ju Yeh, Ping-Yuan Lin, Ming-Huei Liao, Wen-Ling Shih*. Tumor Necrosis Factor-a mediates Pseudo

42、rabies Virus-induced Apoptosis via the Activation of p38 Mitogen-activated Protein Kinase and c-Jun N-terminal Kinase /Stress-activated Protein Kinase Signaling.25. 2007/6 慈濟大學九十六年度學術(shù)研討會。Tsung-Chi Huang, Ming-Huei Liao, Wen-Ling Shih*. Involvement of DNA-damage Pathway in Pseudorabies Virus-induced

43、Apoptosis. 26. 2007/6 慈濟大學九十六年度學術(shù)研討會。Ping-Yuan Lin, Hung-Jen Liu, Ming-Huei Liao, Wen-Ling Shih*. Modulation of p53 activity by Mitogen-activated Protein Kinase pathway and protein kinase C d signaling during Avian Reovirus induced apoptosis.27. 2008/3 第二十三屆生物醫(yī)學學術(shù)研討會，國防大學。林炳源，邱淑君，劉宏仁，廖明輝，施玟玲*。Modula

44、tion of p53 activity by Mitogen-activated Protein Kinase pathway and protein kinase C d signaling during Avian Reovirus induced apoptosis.28. 2008/3 第二十三屆生物醫(yī)學學術(shù)研討會，國防大學。黃琮智，王冠雄，廖明輝，施玟玲*。 Involvement of DNA-damage Pathway in Pseudorabies Virus-induced Apoptosis.29. 2008/3 第二十三屆生物醫(yī)學學術(shù)研討會，國防大學。(獲優(yōu)秀壁報論文

45、獎)葉靜儒，林炳源，廖明輝，施玟玲*。Tumor Necrosis Factor- Mediates Pseudorabies Virus-Induced Apoptosis via The Activation of P38 Mitogen-Activated Protein Kinase and C-Jun N-Terminal Kinase /Stress-Activated Protein Kinase Signaling. 30. 2008/3 第二十三屆生物醫(yī)學學術(shù)研討會，國防大學。陳俊延，廖明輝，施玟玲*。Src-Dependent Caspase Activation in B

46、ovine Ephemeral Fever Virus Induced Apoptosis.31. 2008/3 第二十三屆生物醫(yī)學學術(shù)研討會，國防大學。鄭博勻，廖明輝，徐雪瑩，施玟玲*。Pseudorabies Virus Activates Phosphatidylinositol 3-Kinase/Akt Signaling to Block Caspase-Dependent Apoptosis during Early Stage of Virus Infection.32. 2008/5 慈濟大學九十七年度學術(shù)研討會。葉靜儒，林炳源，廖明輝，施玟玲*。Tumor Necrosis

47、Factor- Mediates Pseudorabies Virus-Induced Apoptosis via The Activation of P38 Mitogen-Activated Protein Kinase and C-Jun N-Terminal Kinase /Stress-Activated Protein Kinase Signaling.33. 2008/5 慈濟大學九十七年度學術(shù)研討會。黃琮智，王冠雄，廖明輝，施玟玲*。 Involvement of DNA-damage Pathway in Pseudorabies Virus-induced Apoptosi

48、s.34. 2008/12/20 畜牧獸醫(yī)研討會，家畜衛(wèi)生試驗所。王嘉裕，施玟玲，劉宏仁，魯懿萍，廖明輝。犬瘟熱病毒血液凝集素蛋白基因之單株抗體製備與檢測試劑開發(fā)。35. 2008/12/20 畜牧獸醫(yī)研討會，家畜衛(wèi)生試驗所。謝宗訓，施玟玲，江強華，尤封陵，廖明輝。犬瘟熱病毒核鞘蛋白基因之分子選殖表現(xiàn)與單株抗體之製備。36. 2009/3/212009/3/22 第二十四屆生物醫(yī)學學術(shù)研討會，國防大學。林炳源，邱淑君，劉宏仁，廖明輝，施玟玲*。Involvement of Akt, NF-B and Stat3 in Avian Reovirus S1133-elicited Inflamma

49、tion Response at the Early Stage of Infection.37. 2009/5/23 九十八年度畜牧獸醫(yī)春季學術(shù)研討會，國立臺灣大學獸醫(yī)專業(yè)學院。張國彬，葉宗明，施玟玲，張清棟，劉宏仁，廖明輝。應(yīng)用聚合酶連鎖反應(yīng)技術(shù)檢測家貓常見疾病。38. 2009/5/23 九十八年度畜牧獸醫(yī)春季學術(shù)研討會，國立臺灣大學獸醫(yī)專業(yè)學院。李美玲，葉宗明，施玟玲，張清棟，劉宏仁，廖明輝。應(yīng)用分子技術(shù)檢測犬隻常見疾病。39. 2009/5/23 九十八年度畜牧獸醫(yī)春季學術(shù)研討會，國立臺灣大學獸醫(yī)專業(yè)學院。林如謙，施玟玲，廖明輝，張清棟，劉宏仁。水楊酸及蛋白酶體抑制劑抑制牛流行熱病毒

50、感染之研究。40. 2009/5/23 九十八年度畜牧獸醫(yī)春季學術(shù)研討會，國立臺灣大學獸醫(yī)專業(yè)學院。黃韋儒，施玟玲，李龍湖，郭耀仁，劉宏仁。家禽里奧病毒抑制宿主細胞cap-dependent轉(zhuǎn)譯作用。41. 2009/10/5 2009 International Symposium on Innovative Agricultural Biotechnology, National Pingtung University of Science and Technology. Hong-Yin Wu, Wen-Ling Shih*. Inhibition of the transcriptio

51、nal activity of Human Hepatitis B virus X protein by Ursolic Acid and Oleanolic Acid.42. 2009/10/5 2009 International Symposium on Innovative Agricultural Biotechnology, National Pingtung University of Science and Technology. Bo-Wei Lin, Chi-I Chang, Wen-Ling Shih*. Inhibition of human hepatitis B v

52、irus replication by screening of natural products43. 2009/10/5 2009 International Symposium on Innovative Agricultural Biotechnology, National Pingtung University of Science and Technology. Chuh-Wei Chuang, Wen-Ling Shih*, Ming-Huei Liao. Induction of autophagy and ER stress Response by Pseudorabies virus in cultured c