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1、一、投稿信1. Dear Dr. Defendi ML:I am sending a manuscript entitled “” by which I should like to submit for possible publication in the journal of - .Yours sincerely2. Dear Dr. A:Enclosed is a manuscript entitled “” by sb, which we are submitting for pu blication in the journal of - . We have chosen this

2、 journal because it deals with - . We believe that sth would be of interest to the journals readers.3. Dear Dr. A:Please find enclosed for your review an original research article, “” by sb. All author s have read and approve this version of t he article, and due care has been taken to ensure the in

3、tegrity of the work. No part of this paper has published or submitte d elsewhere. No conflict of interest exits in the submission of this manuscript, and we have attached to this letter the signed letter granting us permission to use Figure 1 from another source.We appreciate your consideration of o

4、ur manuscript, and we look forward to receiving comments from the reviewers.二、詢問有無收到稿件Dear Editors,We dispatched our manuscript to your journal on 3 August 2006 but have not, as yet, receive acknowledgement of their safe arrival. We fear that may have been lost and should be grateful if you would le

5、t us know whether or not you have received them. If not, we will send our manuscript again. Thank you in advance for your help.三、詢問論文審查回音Dear Editors ,It is more than 12 weeks since I submitted our manuscript (No: for possible publication in your journal. I have not yet rec eived a reply and am wond

6、ering whether you have reached a decision. I should appreciated your letting me know what you have decided as soon as possible.四、關(guān)于論文的總體審查意見1. This is a carefully done study and the findings are of considerable interest. A few minor revision are list below.2. This is a well-written paper containing

7、interesting results which merit publication. For the benefit of the reader, however, a number of points need clarifying and certain statements require further justification. There are given below.3. Although these observation are interesting, they are rather limited and do not advance our knowledge

8、of the subject suffici ently to warrant publication in PNAS. We suggest that the authors try submitting their findings to specialist journal such as 4. Although this paper is good, it would be ever better if some extra data were added.5. This manuscript is not suitable for publication in the journal

9、 of because the main observation it describe was reported 3 years ago in a reputable journal of - .6. Please ask someone familiar with English language to help you rewrite this paper. As you will see, I have made some corr ection at the beginning of the paper where some syntax is not satisfactory.7.

10、 We feel that this potentially interesting study has been marred by an inability to communicate the finding correctly in Engli sh and should like to suggest that the authors seek the advice of someone with a good knowledge of English, preferable nati ve speaker.8. The wording and style of some secti

11、on, particularly those concerning HPLC, need careful editing. Attention should be paid t o the wording of those parts of the Discussion of and Summary which have been underlined.9. Preliminary experiments only have been done and with exception of that summarized in Table 2, none has been repeated. T

12、his is clearly unsatisfactory, particularly when there is so much variation between assays.10. The condition of incubation are poorly defined. What is the temperature? Were antibody used?五、給編輯的回信1. In reply to the referees main criticism of paper, it is possible to say that One minor point raised by

13、 the referee concerns of the extra composition of the reaction mixture in Figure 1. This has now be en corrected. Further minor changes had been made on page 3, paragraph 1 (line 3-8 and 2 (line 6-11. These do not affec t our interpretation of the result.2. I have r ead the referees comments very ca

14、refully and conclude that the paper has been rejected on the sole grounds that it lake toxicity data. I admit that I did not include a toxicity table in my article although perhaps I should have done. This was for the sake of brevity rather than an error or omission.3. Thank you for your letter of a

15、nd for the referees comments concerning our manuscript entitled “”. We have studied thei r comments carefully and have made correction which we hope meet with their approval.4. I enclosed a revised manuscript which includes a report of additional experiments done at the referees suggestion. You wi l

16、 l see that our original findings are confirmed.5. We are sending the revised manuscript according to the comments of the reviewers. Revised portion are underlined in re d.6. We found the referees comments most helpful and have revised the manuscript7. We are pleased to note the favorable comments o

17、f reviewers in their opening sentence.8. Thank you for your letter. I am very pleased to learn that our manuscript is acceptable for publication in Cancer Research with minor revision.9. We have therefore completed a further series of experiments, the result of which are summarized in Table 5. From

18、this we conclude that intrinsic factor is not account.10. We deleted the relevant passage since they are not essential to the contents of the paper.11. I feel that the reviewers comments concerning Figures 1 and 2 result from a misinterpretation of the data.12. We would have include a non-protein in

19、hibitor in our system, as a control, if one had been available.13. We prefer to retain the use of Table 4 for reasons that it should be clear from the new paragraph inserted at the end of the Results section.14. Although reviewer does not consider it is important to measure the temperature of the ce

20、lls, we consider it essential. 15. The running title has been changed to “”.16. The Materials and Methods section now includes details for measuring uptake of isotope and assaying hexokinase.17. The concentration of HAT media (page12 paragraph 2 was incorrectly stated in the original manuscript. Thi

21、s has been re ctified. The authors are grateful to the referees for pointing out their error.18. As suggested by both referees, a discussion of the possibility of laser action on chromosome has been included (page16, paragraph 2.19. We included a new set of photographs with better definition than those originally submitted and to which a scale has bee n added.20. Following the suggestion of the referees, we have redraw Figure 3 and 4.21. Two further papers, published since

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