北京協(xié)和建昊醫(yī)藥技術(shù)開發(fā)有限責(zé)任公司

1、北京協(xié)和建昊醫(yī)藥技術(shù)開發(fā)有限責(zé)任公司Beijing Uuion-Genius Pharmaceutical Technology Ltd 項目領(lǐng)域Testing field序號No.項目名稱Name of study方法號Method codeOECD編號OECD code所需樣品量（克）Needed sample(g)所需時間（天）Needed Time(d)健康毒理Health Effects1急性經(jīng)口毒性試驗Acute Oral Toxicity Test4014012030282急性經(jīng)皮毒性試驗Acute Dermal Toxicity Test4024021020283急性吸入毒性試

2、驗Acute Inhalation Toxicity Test4034032030284急性皮膚刺激性/腐蝕性試驗Acute Dermal Irritation/Corrosion Test4044041020285急性眼刺激性/腐蝕性試驗Acute Eye Irritation/Corrosion Test4054051020286皮膚致敏試驗Skin Sensitization Test4064062030407嚙齒類動物28天反復(fù)經(jīng)口毒性試驗Repeated Dose 28-day Oral Toxicity Study in Rodents4074076008001508嚙齒類動物亞慢

3、性（90天）經(jīng)口毒性試驗Repeated Dose 90-day Oral Toxicity in Rodents408408100020002109非嚙齒類動物亞慢性（90天）經(jīng)口毒性試驗Repeated Dose 90-day Oral Toxicity in Nonrodents4094092000400021010反復(fù)經(jīng)皮毒性：21/28天試驗Repeated Dose Dermal Toxicity:21/28-day Study41041060080015011亞慢性經(jīng)皮毒性：90天試驗Subchronic Dermal Toxicity: 90-day Study41141110

4、00200021012反復(fù)吸入毒性：28天或14天試驗Repeated Dose Inhalation Toxicity: 28/14-day Study41241260080015013亞慢性吸入毒性：90天試驗Subchronic Inhalation Toxicity: 90-day Study4134131000200021014致畸試驗Teratogenicity41441450080012015一代繁殖毒性試驗One-Generation Reproduction Toxicity Study4154151000200018016兩代繁殖毒性試驗Two- Generation Re

5、production Toxicity Study4164161000200024017毒物動力學(xué)試驗Toxicokinetics Study41741720040012018有機(jī)磷化合物急性染毒的遲發(fā)性神經(jīng)毒性試驗Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure41841830409019有機(jī)磷化合物亞慢性（28天）染毒的遲發(fā)性神經(jīng)毒性實驗Delayed Neurotoxicity of Orgarophosphorus Substances: 28-day Repeated Dose

6、Method41941920040015020急性經(jīng)口毒性：固定劑量法Acute Oral Toxicity-Fixed Dose Method42042020402821生殖和發(fā)育毒性篩選試驗Reproduction/Developmental Toxicity Screening Test42142130050015022結(jié)合反復(fù)染毒毒性研究的生殖發(fā)育毒性篩選試驗Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test42242250080021023急

7、性經(jīng)口毒性：急性毒性的階層法Acute Oral Toxicity-Acute Toxic Class Method42342350604024嚙齒類動物的神經(jīng)毒性試驗Neurotoxicity Study in Rodents4244243005009025急性經(jīng)口毒性：上下增減劑量法Acute Oral Toxicity: Up and Down Procedure42542550604026致癌試驗Carcinogenicity Studies4514515000800072027慢性毒性試驗Chronic Toxicity Studies4524523000600036028慢性毒性與

8、致癌性聯(lián)合試驗Combined Chronic Toxicity/Carcinogenicity Studies4534535000800072029細(xì)菌回復(fù)突變試驗Bacterial Reverse Mutation Test471， 472471， 47210206030體外哺乳動物細(xì)胞染色體畸變試驗In vitro Mammalian Chromosome Aberration Test47347310206031哺乳動物紅細(xì)胞微核試驗Mammalian Erythocyte Micronucleus Test47447430503532哺乳動物骨髓染色體畸變試驗Mammalian Bo

9、ne Marrow Chromosome Aberration Test47547510206033體外哺乳動物細(xì)胞基因突變試驗In vitro Mammalian Cell Gene Mutation Test47647610209034黑腹果蠅伴性隱性致死試驗Sex-linked Recessive Lethal Test in Drosophila Melanogaster, SLRL47747710209035嚙齒類動物顯性致死試驗Rodent Dominant Lethal Test4784782004009036哺乳類動物細(xì)胞姐妹染色單體互換體外試驗In vitro Sister

10、Chromatid Exchange Assay in Mammalian Cells47947910209037釀酒酵母基因突變試驗Saccharomyces cerevisiae, Gene Mutation Assay48048010206038釀酒酵母有絲分裂重組試驗Saccharomyces Cerevisiae Mitotic Recombination Assay48148110206039哺乳類動物細(xì)胞DNA損害與修復(fù)/程序外DNA合成體外試驗DNA Damage and Repair/Unscheduled DNA Synthesis in Mammalian Cells i

11、n vitro48248210209040哺乳動物精原細(xì)胞染色體畸變試驗Mammalian Spermatogonial Chromosome Aberration Test48348310209041小鼠斑點試驗Mouse Spot Test4844841002009042小鼠可遺傳易位試驗Mouse Heritable Translocation Assay4854852004009043體內(nèi)哺乳動物肝細(xì)胞程序外DNA合成（UDS）試驗Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo4864861

12、0209044空斑形成細(xì)胞試驗（PFC）Plaque Forming Cell Assay49049010209045遲發(fā)型超敏反應(yīng)試驗Delayed Type Hypersensitivity Test4914911002009046自然殺傷細(xì)胞活性試驗Natural Killer Cell Activity Assay492492102090理化性質(zhì)Physical-chemical property47紫外-可見吸收光譜US-VIS Absorption Spectra10110110060 48熔點/熔點范圍 Melting Point/Melting Range10210210030

13、 49沸點 Boiling Point10310320060 50蒸汽壓 Vapour Pressure104104100180 51水溶解度 Water Solubility10510510090 52吸附/解析 Adsorption/Desorption10610650120 53分配系數(shù)（正辛醇/水）-搖瓶法Partition Coefficient(n-octanol/water-Polarographic Method)10710710090 54液體和固體的密度 Density of Liquids and Solids109109200ml/200g60 55顆粒物粒度分布/纖維

14、長度和直徑分布 Particle Size Distribution/Fibre Length and Diameter Distributions11011010060 56與PH有關(guān)的水解作用Hydrolysis as a Function of Ph11111150300 57分配系數(shù)（正辛醇/水）-高效液相色譜法 Partition Coefficient(n-octanol/water-HPLC Method1171175090 生態(tài)毒理Eco-toxicity58藻類生長抑制試驗 Alga Growth Inhibition Test2012012060 59溞類24hEC50急性

15、活動抑制試驗 Daphnia sp. 24h EC50 Acute Immobilization Test2022022045 60魚類急性毒性試驗 Fish Acute Toxicity Test203203200100 61魚類14天延長毒性試驗 Fish, Prolonged Toxicity Test: 14-day Study204204200100 62鳥類日糧毒性試驗 Avian Dietary Toxicity Test2052052514 63鳥類繁殖試驗Avian Reproduction Test20620623090 64蚯蚓急性毒性試驗Earthworm, Acute

16、 Toxicity Test2072077090 65活性污泥呼吸抑制試驗 Activated Sludge, Respiration Inhibition Test2092092045 66大型溞繁殖試驗 Daphnia magna Reproduction Test211211200180 67蜜蜂急性經(jīng)口毒性試驗Honeybees, Acute oral Toxicity Test21321310090 68蜜蜂急性接觸毒性試驗 Honeybees, Acute Contact Toxicity Test21421410060 69快速生物降解性 Ready Biodegradabili

17、ty3013011090 70改進(jìn)的MITI試驗（I）Modified MITI Test I301C301C10100 71密閉瓶試驗Closed Bottle Test301D301D10100 72改進(jìn)的OECD篩選試驗 Modified OECD Screening Test301E301E10100 73改進(jìn)的半連續(xù)活性污泥（SCAS）試驗 Inherent Biodegradability: Modified SCAS Test302A302A20100 74改進(jìn)的MITI試驗（II） Modified MITI Test II302C302C20100 75土壤固有生物降解能力 Inherent Biodegradability in Soil304A304A100120 76流水式魚類試驗 Bioconcentration:Flow-Through Fish Test3053051000210 77連續(xù)靜態(tài)魚類試驗Bioconcentration: Sequential Static Fish Te